Abstract
The preparation of a series of substituted indoles coupled to six- and seven-membered cyclic lactams is described and their role as human glycogen phosphorylase a inhibitors discussed. The SAR of the indole moiety and lactam ring are presented.
MeSH terms
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Glycogen Phosphorylase / antagonists & inhibitors*
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Humans
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Kinetics
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Models, Molecular
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Molecular Conformation
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Quinolines / chemical synthesis*
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Quinolines / chemistry
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Quinolines / pharmacology*
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Structure-Activity Relationship
Substances
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Enzyme Inhibitors
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Quinolines
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Glycogen Phosphorylase